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Some argue that applying such concepts to normal behaviors such as sex, can be problematic, and suggest that applying medical models such as addiction to human sexuality can serve to pathologise normal behavior and cause harmNeuroscientists, pharmacologists, molecular biologists, and other researchers in related fields have identified the transcriptional and epigenetic mechanisms of addiction pathophysiology. Similarly to other GABAA receptor positive allosteric modulators such as benzodiazepines, barbiturates, and alcohol, tolerance has been found to develop with exposure to increased levels of allopregnanolone and related inhibitory neurosteroids. The variation in joint configuration results in some sacroiliac joints being inherently weaker or more prone to misalignment. Starting in the mid-20th century, psychedelic drugs have been the object of extensive attention in the Western world. Six months later, she became pregnant. 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